PAGNI, Haematology Department, Heraklion Crete, PO 1352 +30 2810-392-344 +30 2810-392-426

Publications

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  1. Myeloid-Derived Suppressor Cells in Hematologic Diseases: Promising Biomarkers and Treatment Targets.Bizymi N, Bjelica S, Kittang AO, Mojsilovic S, Velegraki M, Pontikoglou C, Roussel M, Ersvær E, Santibañez JF, Lipoldová M, Papadaki HA.Hemasphere. 2019 Jan 28;3(1):e168. doi: 10.1097/HS9.0000000000000168. eCollection 2019 Feb. Review.

  2. Altered Monocyte Subsets in Patients with Chronic Idiopathic Neutropenia.Bizymi N, Velegraki M, Damianaki A, Koutala H, Papadaki HA.J Clin Immunol. 2019 Nov;39(8):852-854. doi: 10.1007/s10875-019-00694-5. Epub 2019 Oct 27. No abstract available.

  3. Mavroudi I, Eliopoulos AG, Pontikoglou C, Pyrovolaki K, Damianaki A, Koutala H, Zervou MI, Ximeri M, Mastrodemou S, Kanellou P, Goulielmos GN, Papadaki HA. Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia.Clin Immunol. 2017 Jul 18;183:75-81.

  4. Mastrodemou S, Stalika E, Vardi A, Gemenetzi K, Spanoudakis M, Karypidou M, Mavroudi I, Hadzidimitriou A, Stavropoulos-Giokas C, Papadaki HA, Stamatopoulos K. Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors.Leuk Lymphoma. 2017 Dec;58(12):2926-2933.

  5. Damianaki A, Stagakis E, Mavroudi I, Spanoudakis M, Koutala H, Papadogiannis F, Kanellou P, Pontikoglou C, Papadaki HA. Minor populations of paroxysmal nocturnal hemoglobinuria-type cells in patients with chronic idiopathic neutropenia.Eur J Haematol. 2016 Dec;97(6):538-546.

  6. Palmblad J, Nilsson CC, Höglund P, Papadaki HA. How we diagnose and treat neutropenia in adults.Expert Rev Hematol. 2016 May;9(5):479-87.

  7. Kyritsi EM, Yiakoumis X, Pangalis GA, Pontikoglou C, Pyrovolaki K, Kalpadakis C, Mavroudi I, Koutala H, Mastrodemou S, Vassilakopoulos TP, Vaiopoulos G, Diamanti-Kandarakis E, Papadaki HA, Angelopoulou MK. High Frequency of Thyroid Disorders in Patients Presenting With Neutropenia to an Outpatient Hematology Clinic STROBE-Compliant Article.Medicine (Baltimore). 2015 Jun;94(23):e886.

  8. Zeidler C, Grote UA, Nickel A, Brand B, Carlsson G, Cortesão E, Dufour C, Duhem C, Notheis G, Papadaki HA, Tamary H, Tjønnfjord GE, Tucci F, Van Droogenbroeck J, Vermylen C, Voglova J, Xicoy B, Welte K. Outcome and management of pregnancies in severe chronic neutropenia patients by the European Branch of the Severe Chronic Neutropenia International Registry.Haematologica. 2014 Aug;99(8):1395-402.

  9. Palmblad J, Dufour C, Papadaki HA. How we diagnose neutropenia in the adult and elderly patient.Haematologica. 2014 Jul;99(7):1130-3.

  10. Mastrodemou S, Vazgiourakis V, Velegraki M, Pavlaki K, Goulielmos GN, Papadaki HA. Clonal patterns of X-chromosome inactivation in peripheral blood cells of female patients with chronic idiopathic neutropenia.Haematologica. 2012 Dec;97(12):1931-3.

  11. Pavlaki KI, Kastrinaki MC, Klontzas M, Velegraki M, Mavroudi I, Papadaki HA. Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia.Haematologica. 2012 May;97(5):743-50.

  12. Velegraki M, Koutala H, Tsatsanis C, Papadaki HA. Increased levels of the high mobility group box 1 protein sustain the inflammatory bone marrow microenvironment in patients with chronic idiopathic neutropenia via activation of toll-like receptor 4.J Clin Immunol. 2012 Apr;32(2):312-22.

  13. Gemetzi C, Mavroudi I, Koutala H, Velegraki M, Choulaki C, Damianaki A, Pontikoglou C, Papadaki HA. Lymphopenia in patients with chronic idiopathic neutropenia is associated with decreased number of T-lymphocytes containing T-cell receptor excision circles.Eur J Haematol. 2012 Mar;88(3):210-23.

  14. Pontikoglou C, Kalpadakis C, Papadaki HA. Pathophysiologic mechanisms and management of neutropenia associated with large granular lymphocytic leukemia.Expert Rev Hematol. 2011 Jun;4(3):317-28

  15. Spanoudakis M, Koutala H, Ximeri M, Pyrovolaki K, Stamatopoulos K, Papadaki HA. T-cell receptor Vβ repertoire analysis in patients with chronic idiopathic neutropenia demonstrates the presence of aberrant T-cell expansions.Clin Immunol. 2010 Dec;137(3):384-95.

  16. Pontikoglou C, Papadaki HA. Idiosyncratic drug-induced agranulocytosis: the paradigm of deferiprone.Hemoglobin. 2010 Jun;34(3):291-304.

  17. Eliopoulos DG, Mavroudi I, Pontikoglou C, Ximeri M, Stavroulaki E, Pyrovolaki K, Velegraki M, Spanoudakis M, Goulielmos G, Papadaki HA.The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia.Eur JHaematol. 2009 Dec 1;83(6):535-40.

  18. Papadaki HA, Pontikoglou C. Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia.  Expert Rev Hematol. 2008 Dec;1(2):217-29.

  19. Stamatopoulos K, Papadaki T, Pontikoglou C, Athanasiadou I, Stavroyianni N, Bux J, Batsis I, Pyrovolaki K, Paterakis G, Anagnostou D, Anagnostopoulos A, Papadaki HA. Lymphocyte subpopulation imbalances, bone marrow hematopoiesis and histopathology in rituximab-treated lymphoma patients with late-onset neutropenia.Leukemia. 2008 Jul;22(7):1446-9.

  20. Palmblad J, Papadaki HA. Chronic idiopathic neutropenias and severe congenital neutropenia.Curr Opin Hematol. 2008 Jan;15(1):8-14. Review.

  21. PyrovolakiK, MavroudiI, PapadantonakisN, VelegrakiM, XimeriM, KalpadakisC, GvazavaG, KlausM, EliopoulosGD, PapadakiHA. Transforming growth factor-beta1 affects interleukin-10 production in the bone marrow of patients with chronic idiopathic neutropenia.Eur J Haematol. 2007 Dec;79(6):531-8.

  22. Koumaki V, Damianaki A, Ximeri M, Pontikoglou C, Axioti F, Spanoudakis M, Eliopoulos GD, Papadaki HA. Pro-inflammatory bone marrow milieu in patients with chronic idiopathic neutropenia is associated with impaired local production of interleukin-10.Br J Haematol. 2006 Nov;135(4):570-3.

  23. Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos GD, Papadaki HA. Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia.Exp Hematol. 2006 Oct;34(10):1312-22

  24. Psyllaki M, Damianaki A, Gemetzi C, Pyrovolaki K, Eliopoulos GD, Papadaki HA. Impaired megakaryopoiesis in patients with chronic idiopathic neutropenia is associated with increased transforming growth factor beta1 production in the bone marrow.Br J Haematol. 2006 Sep;134(6):624-31.

  25. Papadaki HA, Damianaki A, Pontikoglou C, Pyrovolaki K, Eliopoulos DG, Stavroulaki E, Eliopoulos GD. Increased levels of soluble flt-3 ligand in serum and long-term bone marrow culture supernatants in patients with chronic idiopathic neutropenia.Br J Haematol. 2006 Mar;132(5):637-9.

  26. Papadaki HA, Pontikoglou C, Eliopoulos DG, Pyrovolaki K, Spyridaki R, Eliopoulos GD. Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly.Am J Hematol. 2006 Feb;81(2):142-4.

  27. Papadaki HA, Pontikoglou C, Stavroulaki E, Eliopoulos DG, Mavroudi I, Spanoudakis M, Eliopoulos GD. Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia.Ann Hematol. 2006 Mar;85(3):170-3.

  28. Papadaki HA, Stamatopoulos K, Damianaki A, Gemetzi C, Anagnostopoulos A, Papadaki T, Eliopoulos AG, Eliopoulos GD. Activated T-lymphocytes with myelosuppressive properties in patients with chronic idiopathic neutropenia.Br J Haematol. 2005 Mar;128(6):863-76.

  29. Papadaki HA, Pontikoglou C, Stavroulaki E, Minadakis G, Eliopoulos DA, Pyrovolaki K, Skordilis P, Eliopoulos GD. High prevalence of Helicobacter pylori infection and monoclonal gammopathy of undetermined significance in patients with chronic idiopathic neutropenia.Ann Hematol. 2005 May;84(5):317-20.

  30. Papadaki HA, Tsatsanis C, Christoforidou A, Malliaraki N, Psyllaki M, Pontikoglou C, Miliaki M, Margioris AN, Eliopoulos GD. Alendronate reduces serum TNFalpha and IL-1beta, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis.J Bone Miner Metab. 2004;22(6):577-87.

  31. Megalakaki A, Mitsouli C, Pontikoglou C, Iakovidou J, Koumaki V, Eliopoulos GD, Papadaki HA. Chronic idiopathic neutropenia preceding polymyalgia rheumatica and acute myeloid leukemia.Ann Hematol. 2004 Dec;83(12):791-2.

  32. Papadaki HA, Kosteas T, Gemetzi C, Damianaki A, Anagnou NP, Eliopoulos GD. Acute myeloid/NK precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia.Ann Hematol. 2004 Jun;83(6):345-8.

  33. Papadaki HA, Kosteas T, Gemetzi C, Christoforidou A, Anagnou NP, Eliopoulos GD. Low serum gamma-glutamyltranspeptidase (GGT) in patients with chronic idiopathic neutropenia is not implicated in the pathophysiology of the disease.Haematologica. 2003 Nov;88(11):ELT32

  34. Papadaki HA, Eliopoulos GD. The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure.Cell Cycle. 2003 Sep-Oct;2(5):447-51. Review.

  35. Koumaki V, Papadaki HA, Stefanaki K, Damianaki A, Gemetzi C, Katonis P, Vrentzos G, Eliopoulos GD. Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia.Ann Hematol. 2003 Oct;82(10):641-5

  36. Person RE, Li FQ, Duan Z, Benson KF, Wechsler J, Papadaki HA, Eliopoulos G, Kaufman C, Bertolone SJ, Nakamoto B, Papayannopoulou T, Grimes HL, Horwitz M. Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2.Nat Genet. 2003 Jul;34(3):308-12

  37. Papadaki HA, Horwitz M, Coulocheri SA, Person RA, Benson KF, Eliopoulos GD. Low levels of serum elastase are not associated with mutations in ELA-2 elastase encoding gene in chronic idiopathic neutropenia.Blood. 2003 Apr 1;101(7):2898-9

  38. Papadaki HA, Eliopoulos AG, Kosteas T, Gemetzi C, Damianaki A, Koutala H, Bux J, Eliopoulos GD. Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells.Blood. 2003 Apr 1;101(7):2591-600.

  39. Papadaki HA, Michelakaki H, Bux J, Eliopoulos GD. Severe autoimmune neutropenia associated with bone marrow sea-blue histiocytosis.Br J Haematol. 2002 Sep;118(4):931.

  40. Papadaki HA, Marsh JC, Eliopoulos GD. Bone marrow stem cells and stromal cells in autoimmune cytopenias.Leuk Lymphoma. 2002 Apr;43(4):753-60. Review.

  41. Palmblad J, Papadaki HA, Eliopoulos G. Acute and chronic neutropenias. What is new?J Intern Med. 2001 Dec;250(6):476-91. Review.

  42.  Papadaki HA, Gibson FM, Psyllaki M, Gordon-Smith EC, Marsh JC, Eliopoulos GD. 162. Assessment of bone marrow stem cell reserve and function and stromal cell function in patients with severe congenital neutropenia.Eur J Haematol. 2001 Oct;67(4):245-51.

  43. Papadaki HA, Kosteas T, Gemetzi C, Alexandrakis M, Psyllaki M, Eliopoulos GD. Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor.Ann Hematol. 2002 Jan;81(1):50-4. Epub 2001 Dec 14.

  44. Papadaki HA, Palmblad J, Eliopoulos GD. Non-immune chronic idiopathic neutropenia of adult: an overview.Eur J Haematol. 2001 Jul;67(1):35-44. Review.

  45. Papadaki HA, Charoulakis NZ, Eliopoulos DG, Psyllaki M, Eliopoulos GD. Patients with non-immune chronic idiopathic neutropenia syndrome have increased splenic volume on ultrasonography.Clin Lab Haematol. 2001 Apr;23(2):111-7.

  46. Papadaki HA, Eliopoulos DG, Valatas V, Eliopoulos GD. Anemia of chronic disease is the more frequent type of anemia seen in patients with chronic idiopathic neutropenia of adults.Ann Hematol. 2001 Apr;80(4):195-200.

  47. Papadaki HA, Eliopoulos DG, Ponticoglou C, Eliopoulos GD. Increased frequency of monoclonal gammopathy of undetermined significance in patients with nonimmune chronic idiopathic neutropenia syndrome.Int J Hematol. 2001 Apr;73(3):339-45.

  48. Papadaki HA, Psyllaki M, Eliopoulos DG, Tsiroyianni A, Eliopoulos GD. Increased frequency and specific reactivity of serum antinuclear antibodies in patients with nonimmune chronic idiopathic neutropenia of adults.Acta Haematol. 2001;105(1):13-20.

  49. Papadaki HA, Eliopoulos GD, Coulocheri SA, Spyropoulou M, Stavropoulos-Giokas C. Increased frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults.Blood. 2001 Jan 15;97(2):580-1.

  50. Papadaki HA, Chatzivassili A, Stefanaki K, Koumaki V, Kanavaros P, Eliopoulos GD. Morphologically defined myeloid cell compartments, lymphocyte subpopulations, and histological findings of bone marrow in patients with nonimmune chronic idiopathic neutropenia of adults.Ann Hematol. 2000 Oct;79(10):563-70.

  51. Papadaki HA, Coulocheri S, Eliopoulos GD. Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines.Am J Hematol. 2000 Dec;65(4):271-7.

  52. Papadaki HA, Palmblad J, Kapsimali V, Anagnou NP, Eliopoulos GD. Assessment of bone marrow stem cell reserve and function and stromal cell function in patients with autoimmune cytopenias.Blood. 2000 Nov 1;96(9):3272-5.

  53. Papadaki HA, Giouremou K, Eliopoulos GD. Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF-beta1 by bone marrow stromal cells.Eur J Haematol. 1999 Sep;63(3):154-62.

  54. Papadaki HA, Xylouri I, Coulocheri S, Kalmanti M, Kafatos A, Eliopoulos GD. Prevalence of chronic idiopathic neutropenia of adults among an apparently healthy population living on the island of Crete.Ann Hematol. 1999 Jul;78(7):293-7.

  55. Papadaki HA, Margioris AN, Miliaki M, Steriopoulos C, Valatas W, Eliopoulos GD. Chronic idiopathic neutropenia of adults is associated with decreased bone mineral density and alterations in bone turnover biochemical markers.Eur J Haematol. 1999 May;62(5):311-6.

  56. Papadaki HA, Eliopoulos GD. Selective loss of peripheral blood CD45RO+ T lymphocytes correlates with increased levels of serum cytokines and endothelial cell-derived soluble cell adhesion molecules in patients with chronic idiopathic neutropenia of adults.Ann Hematol. 1998 Oct;77(4):153-9.

  57. Papadaki HA, Eliopoulos GD. Enhanced neutrophil extravasation may be a contributing factor in the determination of neutropenia in patients with chronic idiopathic neutropenia of adults.Eur J Haematol. 1998 Oct;61(4):272-7.

  58. Papadaki HA, Coulocheri S, Xylouri I, Chatzivassili A, Konsolas J, Katrinakis G, Karkavitsas N, Eliopoulos GD. Defective natural killer cell activity of peripheral blood lymphocytes correlates with the degree of neutropenia in patients with chronic idiopathic neutropenia of adults.Ann Hematol. 1998 Mar-Apr;76(3-4):127-34.

  59. Kyriakou D, Papadaki HA, Sakellariou D, Eliopoulos AG, Kapsimali V, Eliopoulos GD. Flow-cytometric analysis of peripheral blood lymphocytes in patients with chronic idiopathic neutropenia of adults.Ann Hematol. 1997 Sep;75(3):103-10.